I'd like people who've done LSD to post here about experience/info/regrets/etc.

I've been researching this, and it's possibly something I'd like to try. :] I know a guy who can supply it, though he's never done it himself so I don't really know too much about it [other than what erowid has to say about it.]

So post, por favor?

I can give you the unbiased pharmocological pros and cons, but I can't give you any personal experience I'm afraid.

curiousgeorge wrote: I can give you the unbiased pharmocological pros and cons, but I can't give you any personal experience I'm afraid.

Meh. Go for it. Anything would be helpful, thanks.

Coolio.

So LSD= Lysergic Diethylamide Acid. It's related to mescaline, which I think was one of the super trippy drugs that Johnny Depp got wasted on in Fear and Loathing.

It has the capacity to reliably induce states of altered perception without altering the level of consciousness, which is consistent with a heightened sensory awareness but diminished control of incoming sensory information. My notes actually say that it can facilitate 'a feeling of union with the universe.'

It was discovered in 1943 and has no clinical uses at the moment.

So, dosages. 20-50 micrograms can typically start to produce effects on the central nervous system-what exactly they are the notes don't say but they'd be relatively mild. Doses a bit higher (100ug range) cause sympathomimetic effects~ pupillary dilation, tachycardia (heart rate rises), hypertension (blood pressure rises), muscle tremor, nausea and hyperthermia.

It's only around the 200ug mark that you start to get the hallucinogenic effects. So your typical street dose will be around or above 200ugs.

A cool effect is called synasthesia. It's cross-talk between the senses. Basically you can see music, feel smells etc. It's apparently a big cause of bad trips. The effects of a dose typically last for up to 12 hours.

It works by agonising serotonin receptors, which cause the inhibiton of serotonin neurons in the raphe nuclei, leading to your trip. You'll get a rapid tolerance to the CNS effects, but the effects on your cardiovascular system are much slower to be normalised.

The good news is that withdrawal is typically accompanied by few psychological or physiological effects. The bad news is that taking even a single dose can precipitate a latent psychological disease. It doesn't directly cause it, but it can trigger it about if it's already there.

If you need any more I can grab the textbook, that's the lecture notes.

EDIT and NB: The LD50 (Lethal dose that kills 50% of subjects, mice assumably) is 12000ug. Given that hallucinogenic effects kick in around 200ug, you'd have to take a massive amount of acid to kill yourself. The only caveat here is that you take pure, pharmacological grade LSD and you don't mix with anything else. If you break either of these rules the LD50 won't be accurate, and will probably be lower.

God wrote:

I've been researching this, and it's possibly something I'd like to try. :]

Don't even think about it.

The major negative effects of LSD use lay in both psychological harm and physical harm. LSD has been implicated in triggering psychosis including schizophrenia and severe depression. Those who are tripping on LSD are prone to personal injuries including death when moving from their original settings because of the altered awareness of their surroundings and the world at large. Those who take the drug repeatedly have to do so in progressively higher doses to achieve the same effects, which can trigger a whole host of health problems due to the unpredictability of this drug.